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The clinical picture depends on the form and degree of development of agranulocytosis. Generally speaking, the manifestations will be as follows:
Increased body temperature.
Growth depends on the stage of the disorder. As a rule, we are talking hydroxychloroquine a long, constant increase in the number to 37.5-38 degrees Celsius. The condition is well felt. Therefore, patients complain of fever.
Acute phases of the pathological process, for example, the infectious form, give an even greater rise in temperature - up to 39 degrees and even higher. This is already deadly. Moreover, these values are not removed by special means.
But in the case when there are not enough neutrophils and other structures, the symptoms do not go away. Its intensity is only growing. The patient experiences weakness, headaches. There is apathy, a desire to lie down. In this state, a person stays constantly until he undergoes full hydroxychloroquine treatment. Arthralgia. They accompany the patient for a long time. By nature, they resemble those in arthritis..
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If a person suffers from rheumatoid lesions of cartilaginous structures, then a pronounced exacerbation occurs with an increase in temperature, weakness, and the inability to move the limbs normally.
At the local level, swelling, redness is manifested (not always). Also, the patient loses the ability to serve himself in everyday life. Damage to the mucous membranes of the body. A characteristic sign of agranulocytosis is necrotic tissue changes. Mainly the oral cavity suffers.
The soft, hard palate and gums are covered with 2-3 mm ulcers. Gradually they grow, becoming larger until they reach a centimeter or a little more. These structures then break open and begin to disintegrate, leaving wounds. The lesions themselves provoke a secondary infection. If left untreated, rough scars remain. The necrotic process also affects other mucous membranes: intestines, genitals, urethra, etc. )
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The growth is insignificant, but it is there. If the patient is not treated, the likelihood of further oversizing is high. Perhaps the development of hepatitis with all the ensuing consequences: liver dysfunction, failure. As a result - bleeding and critical lethal complications. The coagulability of liquid connective tissue is impaired. It mainly develops against the background of myelotoxic damage to the body in adults.
Signs of general plaquenil.
Outwardly manifests itself in several points: The first is external bleeding. Nasal, from the gums. The intensity is quite high. Especially if hydroxychloroquine is moderate. Further, as the pathological process progresses, the risk of internal intestinal bleeding increases. They are potentially fatal if nothing is done.
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Violations of the structure of blood vessels.
In relatively mild cases, coagulopathy is accompanied by the formation of bruises and hematomas. And spontaneously, for no apparent reason.
Also belching, heartburn, sour taste in the mouth and other similar phenomena.
Their increased fragility. All calibers, including arteries. Basically, the capillaries suffer, which is reflected in the development of bruises. Even outside the physical impact on the tissues of the body.
Digestive tract manifestations.
Constipation, diarrhea, alternating stool disorders are possible. This is a bad signal. It indicates damage to the gastrointestinal tract. Frequent infectious processes. Granulocytes are represented by three types of cells. The main ones are neutrophils. The rest are involved in the fight not so much against the virusmi and bacteria, as much with parasites.
Disorders are characterized by a group of symptoms.
One way or another, they are all part of the structure of immunity. Do not let the infection flare up. Agranulocytosis puts an end to the normal functioning of the protective forces. Hence the pronounced problems with immunity.
Nausea, vomiting, or violent urging after and outside food intake.
Necrotic ulcerative defects on the mucous membrane are a typical symptom of agranulocytosis, which always develops. Gradually, they scar or transform and capture even larger fragments of the organ.